Methylation Stack

Support Optimal Methylation for Whole-Body Wellness

Methylation is a vital cellular process that acts like a biological switch — impacting everything from neurotransmitter balance and detox to cardiovascular and reproductive health. Thorne’s Methylation Stack is a curated bundle of three clinically trusted supplements: Methyl-Guard Plus®, D-5,000, and Magnesium CitraMate. Together, they help maintain healthy methylation pathways, optimize homocysteine levels, and support foundational wellness.*

What’s Inside the Stack

Methyl-Guard Plus®

Thorne’s flagship methylation formula, Methyl-Guard Plus® provides bioactive forms of key B vitamins: 5-MTHF (active folate), methyl-B12, P5P (B6), and R5P (B2), plus betaine (TMG) to support methylation balance and homocysteine metabolism.* It’s designed to promote cognitive function, cardiovascular health, bone strength, and cellular detoxification.*

D-5,000

This high-potency Vitamin D3 supplement delivers 5,000 IU per capsule to support immune health, bone density, muscle function, and cardiovascular wellness.* Vitamin D is also essential for healthy methylation and helps modulate homocysteine pathways.*

Magnesium CitraMate

A bioavailable blend of magnesium citrate and dimagnesium malate, this formula supports nerve transmission, energy production, muscle relaxation, and cardiovascular function.* Magnesium is essential for hundreds of enzymatic reactions, including several that directly influence methylation.*

Why You’ll Love It

• Comprehensive methylation support with active B vitamins*

• Promotes detox, mood, and homocysteine balance*

• Strengthens bones, muscles, and cardiovascular resilience*

• Ideal for those with MTHFR polymorphisms or chronic fatigue*

• Gluten-free, dairy-free, soy-free, and NSF Certified for quality

Free From
GMOs, gluten, dairy, soy, artificial colors, preservatives, and unnecessary fillers.